Introduction
Platelets are fragments of cells which are involved in blood clotting and forming scabs where the skin has been cut or punctured
Blood clotting prevents continued / significant blood loss from wounds
Scab formation seals the wound with an insoluble patch that prevents entry of microorganisms that could cause infection
It remains in place until new skin has grown underneath it, sealing the skin again
How the blood clots
When the skin is broken (i.e. there is a wound) platelets arrive to stop the bleeding
A series of reactions occur within the blood plasma
Platelets release chemicals that cause soluble fibrinogen proteins to convert into insoluble fibrin and form an insoluble mesh across the wound, trapping red blood cells and therefore forming a clot
The clot eventually dries and develops into a scab to protect the wound from bacteria entering
What are fibrinopeptides, and how are they involved in the conversion process?
What is the significance of fibrin cross-linking in clot stability?
How does the body regulate the conversion of fibrinogen to fibrin to prevent excessive clotting?
What medical conditions can affect the conversion of fibrinogen to fibrin?
How do anticoagulant medications interfere with the conversion of fibrinogen to fibrin?